High Pressure Vessels for Pharmaceutical | Roben Manufacturing
High Pressure Vessels for the Pharmaceutical Industry
The pharmaceutical industry utilizes high pressure vessels for synthesizing active pharmaceutical ingredients (APIs), purifying compounds, and creating advanced drug delivery systems. These vessels must meet exacting standards for cleanliness, documentation, and regulatory compliance while delivering the precision control required for pharmaceutical-grade production. From high pressure hydrogenation of organic intermediates to supercritical CO2 extraction of natural compounds, high pressure technology is essential to modern drug manufacturing.
Pharmaceutical Industry Requirements
Pharmaceutical high pressure vessels require FDA cGMP compliance with documented design, fabrication, and testing procedures. Surfaces must be electropolished to minimize contamination risk and enable thorough cleaning validation. Materials must be compatible with solvents, intermediates, and APIs without leaching or catalyzing degradation. Full traceability of materials, welding, and inspection is mandatory. Equipment must integrate with facility cleaning-in-place (CIP) and sterilization-in-place (SIP) systems.
High Pressure Vessel Types
Roben Manufacturing provides pharmaceutical customers with:
• High pressure hydrogenation reactors
• Supercritical CO2 extractors
• High pressure crystallizers
• API synthesis reactors
• Solvent recovery vessels
• High pressure autoclaves
• Pharmaceutical pressure filters
• Sterile high pressure vessels
Key Applications
• API hydrogenation
• Natural product extraction
• Supercritical chromatography
• High pressure sterilization
• Crystallization under pressure
• Solvent purification
• Catalyst activation
• Polymer drug delivery systems
Certifications & Standards
All Roben high pressure vessels for pharmaceutical are manufactured in accordance with:
• ASME Boiler and Pressure Vessel Code Section VIII, Division 3
• ASME Section X (for composite pressure vessels)
• European Pressure Equipment Directive (PED)
• AD 2000-Merkblatt HP 0 (high pressure applications)
Additional industry-specific certifications and standards are maintained as required for specific applications.
Why Pharmaceutical Companies Choose Roben
With over 65 years serving the pharmaceutical industry, Roben Manufacturing understands the unique demands of your applications. Our engineering team brings deep experience with industry-specific requirements, materials challenges, and regulatory frameworks. From initial concept through delivery and support, we partner with customers to deliver high pressure vessels that perform reliably in the most demanding service conditions.
Frequently Asked Questions
What pressure ranges are available for pharmaceutical applications?
Roben Manufacturing fabricates high pressure vessels across a wide pressure range, from 1,000 PSI to over 60,000 PSI depending on application requirements. Our ASME Section VIII, Division 3 certification enables us to design and build vessels for the most demanding pharmaceutical pressure requirements.
Can you match existing equipment specifications?
Yes, Roben Manufacturing routinely fabricates replacement vessels matched to existing equipment specifications. We can work from original drawings, field measurements, or reverse engineering to deliver compatible replacements that meet current code requirements.
What is the typical lead time?
Lead times vary based on vessel complexity, size, materials, and current production schedule. Standard high pressure vessels typically require 12-20 weeks, while complex or large-scale projects may require longer. Contact our team for project-specific timelines.
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Request a Quote for Pharmaceutical High Pressure Vessels
Contact Roben Manufacturing to discuss your pharmaceutical high pressure vessel requirements.
Phone: (732) 364-6000
Email: sales@robenmfg.com
Address: 760 Vassar Avenue, Lakewood, NJ 08701
www.robenmfg.com
